Hadrian's Villa is a UNESCO World Heritage Site and important cultural and archaeological site. It is also a major tourist destination along with the nearby Villa d'Este and the town of Tivoli. The Academy of the villa was placed on the 100 Most Endangered Sites 2006 list of the World Monuments Watch because of the rapid deterioration of the ruins.

The city is mainly famous for the ruins of the ancient city of Pompeii, located in the zone of Pompei Scavi. The Shrine of Our Lady of Pompei, dedicated to Our Lady of the Rosary, has become a site for Catholic pilgrimages in recent years.

The Amalfi Coast is a stretch of coastline on the southern coast of the Sorrentine Peninsula in the Province of Salerno in Southern Italy. The Amalfi Coast is a popular tourist destination for the region and Italy as a whole, attracting thousands of tourists annually. During the 10th–11th centuries, the Duchy of Amalfi existed on the territory of the Amalfi Coast, centered in the town of Amalfi.

The historic centre of Siena has been declared by UNESCO a World Heritage Site. It is one of the nation's most visited tourist attractions, with over 163,000 international arrivals in 2008. Siena is famous for its cuisine, art, museums, medieval cityscape and the Palio, a horse race held twice a year.

Florence is known as the "cradle of the Renaissance" for its monuments, churches and buildings. The best-known site of Florence is the domed cathedral of the city, Santa Maria del Fiore, known as The Duomo, built by Filippo Brunelleschi. The dome, 600 years after its completion, is still the largest dome built in brick and mortar in the world.

"The leaning Tower of Pisa", is the most famous image of the city, it is one of many works of art and architecture in the city's Piazza del Duomo, also known, since the 20th century, as Piazza dei Miracoli (Square of Miracles), to the north of the old town center. The Piazza del Duomo also houses the Duomo (the Cathedral), the Baptistry and the Campo Santo (the monumental cemetery).

Cascia was the home of Saint Rita of Cascia, who was born in the nearby frazione of Roccaporena in 1381 and died there in 1457. After her canonization in 1900, a large shrine was built in Cascia, which is still an important place of pilgrimage; and the house where she was born may still be visited.

It was the birthplace of St. Francis, who founded the Franciscan religious order in the town in 1208, and St. Clare (Chiara d'Offreducci), the founder of the Poor Sisters, which later became the Order of Poor Clares after her death. The 19th-century Saint Gabriel of Our Lady of Sorrows was also born in Assisi.